#6823 THE NUTRITIONAL AND NEPHROLOGICAL IMPACT OF A LOW-NORMAL PROTEIN HIGH CALORIE DIET ON THE ONCOLOGICAL SOLITARY KIDNEY: TIME FOR A NEW PERSPECTIVE?

Abstract Background and Aims Nutritional therapy (NT) based on controlled protein intake represents a cornerstone in the management of chronic kidney disease (CKD). However international guidelines do not precisely define an adequate for nephrological patients affected by cancer, onco-nephrological ones. Among them, there is precise asset where personalized nutritional strategy can make difference; oncological who remain with solitary due to radical nephrectomy renal cancer. In fact, acute decrease GFR loss entire leads these develop mild severe stage CKD this pathological condition should require diet restriction upon levels. However, routinary clinical practice cohort tend be followed oncologists apply completely opposite approach high presence cancer order avoid catabolism, malnutrition sarcopenia. The aim our study was investigate whether Low-Normal Protein High Calorie (LNPHC) nephrologist-nutritionist combined (NNCA) aimed at also effective improving status without compromising function metabolism. Method A consecutive 44 pts enrolled Urological Department San Raffaele Scientific Institute between 2018-2021. Inclusion criteria were: Age (>18 years old), eGFR (<60 ml/min/1.73), Malnutritional Screening Tool (MST<2), Solitary informed consent (signed). Each patient underwent initial evaluation subsequently subjected conventional LNPHC integrated aproteic foods (0,7-1 g/Kg/die: calories: 30-35 kcal per kg body weight/die) period 6 months (+/- 2 moths). estimated Glomerular Filtration Rate (CKD-EPI 2021 Creatinin formula), comorbidities status. MST, Body Mass Index (BMI), Phase Angle (PA), Fat percentage (FM%), Fat-Free (FFMI), cell mass index (BCMI), extracellular/intracellular water ratio (ECW/ICW), waist/hip circumference (WHC), lab test exams variables were examined baseline after months. Statistical analysis: Kruskal-Wallis rank sum test; Data R programming language RStudio development environment. Results Descriptive analysis showed Table 1. Our results clearly highlighted that able generate significant improvement all investigated parameters (Table 3) avoiding or catabolism. Moreover, regarding asset, responsible urea, most important parameter influencing general non-significant increase serum creatinine therefore related augmented muscle 4). Conclusion new therapeutic